While it is true that most murders are classified as murders by acquaintances, most people, including apparently “Mr. Holmes,” don’t have a clue what the term means. For example, most “acquaintances” are members of rival gangs. Acquaintances also involve people who have perceived financial relations. If a cab driver picks up a fare and then the fare kills the cab driver, that is classified as an acquaintance murder. But if a person comes up to the side of the cab and murders the cab driver, that would be classified as a stranger murder. These are hardly the friends, spouses, and business associates that Holmes refers to.
When you read the Antis bemoan how people are killed by “acquaintance” according to the FBI, you may want to know how the Feds actually qualify the word for their stats.